Ignashina E V, Pivnik A V, Shilin D E, Nasibov O M, Margolin O V, Pustovoĭt L A
Ter Arkh. 1997;69(11):71-3.
A menstrual function was studied in 24 females treated by drugs for advanced stages of Hodgkin's disease. 17 of them received oral contraceptives for preventing gonadotoxic effect of cytostatic agents (the study group). 7 women did not use contraceptives (the control group). After chemotherapy menstrual cycle was normal in 88.2% of patients of the study group, whereas in 71.4% of controls artificial menopause developed. Oral contraceptives can be recommended to protect the ovaries in the course of chemotherapy.
对24例接受药物治疗的晚期霍奇金病女性的月经功能进行了研究。其中17例接受口服避孕药以预防细胞毒性药物的性腺毒性作用(研究组)。7名女性未使用避孕药(对照组)。化疗后,研究组88.2%的患者月经周期正常,而对照组71.4%的患者出现了人工绝经。在化疗过程中,可推荐使用口服避孕药来保护卵巢。