Hiyoshi M, Takubo T, Tagawa S, Hashimoto S, Tatsumi N
Department of Laboratory Medicine, Osaka City University Medical School.
Kansenshogaku Zasshi. 1997 Dec;71(12):1257-60. doi: 10.11150/kansenshogakuzasshi1970.71.1257.
Active cytomegalovirus (CMV) infection was treated successfully by only CMV antibody-enriched immunoglobulin (CMV-IG) in a renal transplant recipient. CMV-IG was injected at 86 mg/kg i.v. twice a day for a total of 16 days (4 plus 12 days, interrupted by a pause of 4 days), followed by weekly i.v. injection of 86 mg/kg (7 weeks). Active CMV infection was diagnosed on the basis of DNAemia in plasma, by a newly developed CMV polymerase chain reaction (PCR) test (AMPLICOR CMV). The disappearance of CMV from plasma was confirmed by this PCR test. It seems that single CMV-IG therapy is worth consideration for the treatment of CMV infection.
在一名肾移植受者中，仅使用富含巨细胞病毒（CMV）抗体的免疫球蛋白（CMV-IG）就成功治疗了活动性CMV感染。CMV-IG以86mg/kg静脉注射，每天两次，共16天（4天加12天，中间停顿4天），随后每周静脉注射86mg/kg（共7周）。通过新开发的CMV聚合酶链反应（PCR）检测（AMPLICOR CMV），根据血浆中的病毒血症诊断为活动性CMV感染。通过该PCR检测证实了CMV从血浆中消失。看来单一的CMV-IG疗法值得考虑用于治疗CMV感染。
