Debure A, Celton J L, Cartron J, Rouzioux C, Chkoff N, Berche P, Kreis H
Départment de Néphrologie, Hôpital Necker, Paris, France.
Lancet. 1988 Dec 10;2(8624):1338-40. doi: 10.1016/s0140-6736(88)90871-9.
Cytomegalovirus (CMV) infections in renal transplant recipients must be diagnosed rapidly, since they can be life-threatening unless chemotherapy is started early. Detection of granulocyte-associated immunoglobulins was compared with conventional virological methods for diagnosis of CMV infection in 71 renal transplant recipients. The granulocyte-associated immunoglobulin test (GAIT) was positive in 31 of 34 patients with proven CMV infections on the day of admission. By conventional virological criteria the diagnosis of active CMV infection could be made only 3-24 days later. The GAIT remained negative in 14 healthy transplant recipients, but it was positive in 9 of 23 patients with non-CMV-related post-transplantation complications. The GAIT, which is not a virological method, could be useful for rapid diagnosis of CMV infection; its sensitivity was 0.91 and specificity 0.82 (for patients without detectable immunoglobulins on erythrocytes or platelets) and the processing time is only 3 h.
肾移植受者的巨细胞病毒（CMV）感染必须迅速诊断，因为除非尽早开始化疗，否则可能危及生命。在71例肾移植受者中，将粒细胞相关免疫球蛋白检测与诊断CMV感染的传统病毒学方法进行了比较。在34例入院当天确诊为CMV感染的患者中，有31例粒细胞相关免疫球蛋白试验（GAIT）呈阳性。按照传统病毒学标准，只能在3 - 24天后做出活动性CMV感染的诊断。14例健康移植受者的GAIT仍为阴性，但在23例非CMV相关移植后并发症患者中，有9例呈阳性。GAIT并非病毒学方法，但可用于CMV感染的快速诊断；其敏感性为0.91，特异性为0.82（针对红细胞或血小板上无可检测免疫球蛋白的患者），且检测过程仅需3小时。
