van den Bent M J, Hilkens P H, Sillevis Smitt P A, van Raaij-van den Aarssen V J, Bontenbal M, Verweij J
Department of Neuro-Oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Neurology. 1998 Feb;50(2):563-4. doi: 10.1212/wnl.50.2.563.
Specific causes for Lhermitte's sign (LS) in cancer patients are spinal cord compression, radiation therapy to the spinal cord, and cisplatin chemotherapy. We observed a transient LS in five of 87 patients treated with more than two cycles of 100 mg/m2 docetaxel (Taxotere). LS developed either concurrently or after the onset of docetaxel-induced sensory neuropathy, and disappeared after the discontinuation or dose reduction of chemotherapy.
