New P Z, Jackson C E, Rinaldi D, Burris H, Barohn R J
Department of Medicine/Neurology, University of Texas Health Science Center, San Antonio 78284-7883, USA.
Neurology. 1996 Jan;46(1):108-11. doi: 10.1212/wnl.46.1.108.
Docetaxel (Taxotere), a semisynthetic analogue of the antitumor agent paclitaxel, inhibits tubulin depolymerization. Paclitaxel produces a peripheral neuropathy. This study delineates clinically and electrophysiologically the characteristics of a peripheral neuropathy due to docetaxel. In 186 patients receiving docetaxel in phase I and phase II protocols, we performed serial neurologic exams. As patients became symptomatic, quantitative sensory testing and nerve conduction studies were done. Twenty-one patients developed mild to moderate sensory neuropathy on taxotere at a wide range of cumulative doses (50 to 750 mg/m2) and dose levels (10 to 115 mg/m2). Ten of these patients also developed weakness of varying degree in proximal and distal extremities. Nine of the 21 patients had received neurotoxic chemotherapy before; 16 were treated with docetaxel at a dose level of 100 to 115 mg/m2. In summary, docetaxel produced a sensorimotor peripheral neuropathy in 11% of our patient population.
多西他赛（泰索帝）是抗肿瘤药物紫杉醇的半合成类似物，可抑制微管蛋白解聚。紫杉醇会导致周围神经病变。本研究从临床和电生理方面描述了多西他赛所致周围神经病变的特征。在186例接受I期和II期方案多西他赛治疗的患者中，我们进行了系列神经学检查。当患者出现症状时，进行了定量感觉测试和神经传导研究。21例患者在接受不同累积剂量（50至750mg/m²）和剂量水平（10至115mg/m²）的泰索帝治疗时出现了轻至中度感觉神经病变。其中10例患者还出现了不同程度的近端和远端肢体无力。21例患者中有9例之前接受过神经毒性化疗；16例接受了剂量水平为100至115mg/m²的多西他赛治疗。总之，多西他赛在我们11%的患者中导致了感觉运动性周围神经病变。
