Carlier M F
Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Curr Opin Cell Biol. 1998 Feb;10(1):45-51. doi: 10.1016/s0955-0674(98)80085-9.
Actin-based motility processes are tightly linked to the rapid turnover of actin filaments. Factors that control the steady state of actin assembly, such as capping proteins and actin-depolymerizing factor/cofilin, directly affect motility. Actin-depolymerizing factor increases the treadmilling of actin filaments in vitro and in vivo. Cellular factors that are involved in linking initiation of barbed end assembly to cell signaling are being identified using Listeria monocytogenes and Saccharomyces cerevisiae as model systems.
基于肌动蛋白的运动过程与肌动蛋白丝的快速周转紧密相连。控制肌动蛋白组装稳态的因素，如封端蛋白和肌动蛋白解聚因子/丝切蛋白，直接影响运动。肌动蛋白解聚因子在体外和体内均能增加肌动蛋白丝的踏车行为。利用单核细胞增生李斯特菌和酿酒酵母作为模型系统，正在鉴定参与将肌动蛋白丝的带刺末端组装起始与细胞信号传导相联系的细胞因子。
