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酵母中Rho家族小GTP结合蛋白对肌动蛋白细胞骨架重组的调控

Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast.

作者信息

Tanaka K, Takai Y

机构信息

Department of Molecular Biology and Biochemistry, Osaka University Medical School, Japan.

出版信息

Curr Opin Cell Biol. 1998 Feb;10(1):112-6. doi: 10.1016/s0955-0674(98)80093-8.

DOI:10.1016/s0955-0674(98)80093-8
PMID:9484602
Abstract

Accumulating evidence indicates that Rho family small GTP-binding proteins regulate reorganization of the actin cytoskeleton. There are members of the Rho family in the budding yeast Saccharomyces cerevisiae, in which powerful molecular genetical approaches are applicable. Recent identification of regulators and targets of the Rho family members has enhanced our understanding of the regulation and modes of action of Rho family members in reorganization of the actin cytoskeleton.

摘要

越来越多的证据表明，Rho家族小GTP结合蛋白调节肌动蛋白细胞骨架的重组。在出芽酵母酿酒酵母中存在Rho家族成员，在其中可以应用强大的分子遗传学方法。最近对Rho家族成员的调节因子和靶标的鉴定增强了我们对Rho家族成员在肌动蛋白细胞骨架重组中的调节和作用模式的理解。

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