[Animal experiments on the induction of humoral antibodies by repeated implantations of dental gelatin and dried fibrin foam].

An attempt was made to demonstrate humoral antibodies against porcine and bovine protein in the sera of guinea pigs following repeated subcutaneous implantation of Gelastypt, Gelfoam, and Fibrospum. Precipitated antibodies against porcine protein could not be demonstrated with the agar gel double diffusion test in the sera of those animals in which gelatin substances had been implanted (starting protein: porcine collagen). Precipitated antibodies against bovine protein were demonstrable in the sera of all animals treated with Fibrospum (starting protein: bovine fibrin). The active hemagglutination test with porcine erythrocytes using sera taken from animals treated with gelatin substances showed a positive to high antibody titer in three cases. The same test carried out with bovine erythrocytes and sera from animals treated with Fibrospum showed positive to high antibody titer for all animals tested.