[Animal experimental studies on the biocompatibility of resorbable gelatin sponges and dry fibrin foam].

Histologic specimens taken from the implantation site and the regional lymph nodes up to four weeks after subcutaneous implantation of Gelastypt S (Höchst AG), Gelfoam (Upjohn), and Fibrospum (Promonta) into the upper hind leg of guinea pigs were examined. Similar tissue reactions were observed with Gelastypt S and Gelfoam; the reactions did not differ appreciably from those normally occurring in the context of wound healing. The predominance of round cell infiltrate and the appearance of giant cells in connection with Fibrospum may indicate an immunogenetic potency of the substance. No signs of beginning resorption could be observed four weeks later.