Pinheiro A L, de Castro J F, Thiers F A, Cavalcanti E T, Rêgo T I, de Quevedo A S, Lins A J, Aca C R
Departamento de Prótese e Cirurgia Buco-Facial, Universidade Federal de Pernambuco, Recife, Brasil.
Braz Dent J. 1997;8(1):21-5.
The use of monofilament nonabsorbable suture materials is not common in Dentistry. Although it is known that multifilament suture materials induce greater cellular reaction, most Dentists prefer to use cotton and silk. Rigidity and package memory are disadvantages of monofilament nonabsorbable suture materials. A new material, Polybutester (Novafil), has been used successfully in Medicine but its use is not common in Dentistry. Seventy male and female Wistar rats were used to study the clinical response of skin and abdominal wall muscle to the use of Novafil and nylon sutures. Under general anesthesia, standard wounds were created in the dorsum and abdomen of the animals and sutured with either Novafil or nylon. The animals were sacrificed immediately, 12, 24, and 72 hours and at 4, 5 and 7 days to evaluate the clinical aspect of both wounds. Polybutester presented some advantages such as strength, lack of package memory, elasticity and flexibility which made suturing quicker and easier. Some subjects presented abdominal wound edema during the period and six animals developed infection of abdominal wounds within seven days. These initial findings show that Novafil is easy to handle and would be better tolerated in the mouth than nylon resulting in less discomfort for the patient. Novafil can be used safely on skin and mucosal wounds and, if necessary, it can be used in internal sutures because it irritates less than nylon.
单丝不可吸收缝合材料在牙科领域并不常用。尽管已知多丝缝合材料会引发更强的细胞反应，但大多数牙医还是更喜欢使用棉线和丝线。单丝不可吸收缝合材料的缺点是硬度和包装记忆性。一种新型材料聚丁酯（诺菲）已在医学领域成功应用，但其在牙科领域的使用并不普遍。本研究选用70只Wistar大鼠，旨在研究皮肤和腹壁肌肉对诺菲和尼龙缝合线的临床反应。在全身麻醉下，在动物的背部和腹部制造标准伤口，并用诺菲或尼龙进行缝合。在术后即刻、12小时、24小时、72小时以及4天、5天和7天处死动物，以评估两种伤口的临床情况。聚丁酯具有一些优点，如强度高、无包装记忆性、有弹性和柔韧性，这使得缝合更快、更容易。在此期间，部分实验对象出现腹部伤口水肿，7天内有6只动物发生腹部伤口感染。这些初步研究结果表明，诺菲易于操作，在口腔中比尼龙更易耐受，给患者带来的不适更少。诺菲可安全用于皮肤和黏膜伤口，如有必要，也可用于内部缝合，因为它比尼龙的刺激性更小。
