来自HIV-1阳性患者的循环免疫复合物可诱导正常淋巴细胞凋亡。
Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes.
作者信息
Aceituno E, Castañón S, Jiménez C, Subirá D, De Górgolas M, Fernández-Guerrero M, Ortíz F, García R
机构信息
Department of Immunology, Fundación Jiménez Díaz, Madrid, Spain.
出版信息
Immunology. 1997 Nov;92(3):317-20. doi: 10.1046/j.1365-2567.1997.00361.x.
Abstract
Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus-1-positive (HIV-1+) patients (CIC-HIV+), composed of anti-HIV-HIV-Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)-activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4+ lymphocytes as demonstrated by double binding of CIC-HIV+ and anti-CD4 on apoptosis cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC-HIV+ apoptosis inducers belong mainly to asymptomatic HIV-infected patients, indicating that immune complexes from these patients can destroy CD4+ lymphocytes.
摘要
从67例人类免疫缺陷病毒1型阳性（HIV-1+）患者中的49例患者血清中分离出的免疫复合物（CIC-HIV+），由抗HIV-HIV抗原组成，可诱导正常植物血凝素（PHA）激活的淋巴细胞凋亡。通过碘化丙啶染色检测到DNA降解。如CIC-HIV+与抗CD4在凋亡细胞上的双重结合所示，这种活性针对CD4+淋巴细胞。Fas抗原的表达先于凋亡现象。CIC-HIV+凋亡诱导剂主要属于无症状HIV感染患者，这表明这些患者的免疫复合物可破坏CD4+淋巴细胞。
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