每日一次的氟氢缩松胶带与每日两次的二氟拉松双醋酸酯软膏治疗银屑病的疗效比较
Comparative efficacy of once-daily flurandrenolide tape versus twice-daily diflorasone diacetate ointment in the treatment of psoriasis.
作者信息
Krueger G G, O'Reilly M A, Weidner M, Dromgoole S H, Killey F P
机构信息
Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
出版信息
J Am Acad Dermatol. 1998 Feb;38(2 Pt 1):186-90. doi: 10.1016/s0190-9622(98)70238-5.
BACKGROUND
Flurandrenolide tape has recently been listed as a group I topical corticosteroid. There are no studies that compare this product to group I ointments in the treatment of steroid-responsive dermatoses.
OBJECTIVE
Our purpose was to determine the relative efficacy of flurandrenolide (4 microg/cm2) tape versus 0.05% diflorasone diacetate ointment in plaque psoriasis.
METHODS
Thirty patients participated in an investigator-blinded, randomized, bilateral paired-comparison study of flurandrenolide tape applied to lesions of one side of the body once daily for up to 16 hours versus diflorasone diacetate ointment applied contralaterally twice daily. Lesions were assessed at baseline, then reevaluated at 2 and 4 weeks.
RESULTS
Flurandrenolide tape-treated plaques showed consistently greater clearing in terms of erythema, scaling, induration, and treatment success for all plaques, as well as the subset of knee and elbow plaques, when compared with the lesions receiving diflorasone diacetate ointment.
CONCLUSION
The efficacy of flurandrenolide tape in the treatment of psoriatic plaques surpasses that of diflorasone diacetate ointment.
背景
氟氢缩松胶带最近被列为I类外用皮质类固醇。尚无研究将该产品与I类软膏在治疗类固醇反应性皮肤病方面进行比较。
目的
我们的目的是确定氟氢缩松（4微克/平方厘米）胶带与0.05%双氟拉松双醋酸酯软膏治疗斑块状银屑病的相对疗效。
方法
30名患者参与了一项研究者盲法、随机、双侧配对比较研究，一侧身体的皮损每日一次应用氟氢缩松胶带，持续16小时，对侧皮损每日两次应用双氟拉松双醋酸酯软膏。在基线时对皮损进行评估，然后在2周和4周时重新评估。
结果
与接受双氟拉松双醋酸酯软膏治疗的皮损相比，氟氢缩松胶带治疗的斑块在红斑、鳞屑、硬结方面以及所有斑块、膝部和肘部斑块亚组的治疗成功率方面均持续显示出更大程度的消退。
结论
氟氢缩松胶带治疗银屑病斑块的疗效超过双氟拉松双醋酸酯软膏。
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