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人类中性粒细胞趋化作用对钙内流的需求:氯化镧的抑制作用

Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride.

作者信息

Boucek M M, Snyderman R

出版信息

Science. 1976 Sep 3;193(4256):905-7. doi: 10.1126/science.948752.

Abstract

Calcium fluxes of human neutrophils measured in the presence of chemotactically active serum showed a marked stimulation of calcium-45 uptake from the media. Chemotactically inactive serum did not cause an influx of calcium. The magnitude of the calcium influx due to activated serum is sufficient to trigger contractile systems previously described in muscle cells. Lanthanum chloride inhibited the chemotactic response of human neutrophils to activated serum. Lanthanum in concentrations that suppressed chemotaxis also inhibited the calcium influx caused by activated serum. Lanthanum in concentrations that suppressed chemotaxis also inhibited the calcium influx caused by activated serum. The data support a direct role of calcium influx in chemotaxis of neutrophils.

摘要

在存在趋化活性血清的情况下测量的人类中性粒细胞的钙通量显示,从培养基中摄取钙-45有显著刺激。趋化无活性血清不会引起钙内流。活化血清引起的钙内流幅度足以触发先前在肌肉细胞中描述的收缩系统。氯化镧抑制人类中性粒细胞对活化血清的趋化反应。抑制趋化作用的氯化镧浓度也抑制活化血清引起的钙内流。抑制趋化作用的氯化镧浓度也抑制活化血清引起的钙内流。这些数据支持钙内流在中性粒细胞趋化中起直接作用。

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