Arras M, Mollnau H, Strasser R, Wenz R, Ito W D, Schaper J, Schaper W
Max-Planck-Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany.
Nat Biotechnol. 1998 Feb;16(2):159-62. doi: 10.1038/nbt0298-159.
Microspheres offer the possibility of local noninvasive delivery of drugs over an extended period of time. We adsorbed fibroblast growth factor (FGF) to microspheres of precapillary size that were injected via a coronary catheter. We showed that FGF was released from these microspheres and taken up by endothelial cells, which proliferated following translocation of FGF to the nucleus. This method for application of growth factors allows the precise delivery of angiogenic substances to any selected part of the heart or other organs without causing inflammation or ischemia.
微球提供了在较长时间内局部无创给药的可能性。我们将成纤维细胞生长因子（FGF）吸附到通过冠状动脉导管注射的毛细血管前尺寸的微球上。我们发现FGF从这些微球中释放出来并被内皮细胞摄取，在内皮细胞中，FGF转位至细胞核后会发生增殖。这种应用生长因子的方法能够将血管生成物质精确地递送至心脏或其他器官的任何选定部位，而不会引起炎症或局部缺血。
