心血管基因递送：光明大道即将开启。
Cardiovascular gene delivery: The good road is awaiting.
作者信息
Brewster L P, Brey E M, Greisler H P
机构信息
Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
出版信息
Adv Drug Deliv Rev. 2006 Jul 7;58(4):604-29. doi: 10.1016/j.addr.2006.03.002.
Abstract
Atherosclerotic cardiovascular disease is a leading cause of death worldwide. Despite recent improvements in medical, operative, and endovascular treatments, the number of interventions performed annually continues to increase. Unfortunately, the durability of these interventions is limited acutely by thrombotic complications and later by myointimal hyperplasia followed by progression of atherosclerotic disease over time. Despite improving medical management of patients with atherosclerotic disease, these complications appear to be persisting. Cardiovascular gene therapy has the potential to make significant clinical inroads to limit these complications. This article will review the technical aspects of cardiovascular gene therapy; its application for promoting a functional endothelium, smooth muscle cell growth inhibition, therapeutic angiogenesis, tissue engineered vascular conduits, and discuss the current status of various applicable clinical trials.
摘要
动脉粥样硬化性心血管疾病是全球主要的死亡原因。尽管近年来在药物、手术和血管内治疗方面有所改善，但每年进行的干预数量仍在持续增加。不幸的是，这些干预的耐久性在急性期受到血栓形成并发症的限制，后期则受到肌内膜增生的限制，随后随着时间的推移动脉粥样硬化疾病不断进展。尽管对动脉粥样硬化疾病患者的医疗管理有所改善，但这些并发症似乎仍然存在。心血管基因治疗有可能在临床上取得重大进展以限制这些并发症。本文将综述心血管基因治疗的技术方面；其在促进功能性内皮、抑制平滑肌细胞生长、治疗性血管生成、组织工程血管导管方面的应用，并讨论各种适用临床试验的现状。
相似文献
1
Cardiovascular gene delivery: The good road is awaiting.心血管基因递送：光明大道即将开启。
Adv Drug Deliv Rev. 2006 Jul 7;58(4):604-29. doi: 10.1016/j.addr.2006.03.002.
2
3
Angiogenic Growth Factors for Coronary Artery Disease: Current Status and Prospects.用于冠状动脉疾病的血管生成生长因子：现状与前景
J Cardiovasc Pharmacol Ther. 2018 Mar;23(2):130-141. doi: 10.1177/1074248417735399. Epub 2017 Oct 12.
4
Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis.血管内皮生长因子基因治疗冠心病：系统评价和荟萃分析。
Cardiovasc Ther. 2018 Oct;36(5):e12461. doi: 10.1111/1755-5922.12461. Epub 2018 Aug 15.
5
Therapeutic angiogenesis with vascular endothelial growth factor in peripheral and coronary artery disease: a review.血管内皮生长因子在周围动脉疾病和冠状动脉疾病中的治疗性血管生成：综述
Int J Cardiovasc Intervent. 2003;5(1):27-34. doi: 10.1080/14628840304612.
6
Novel molecular targets for coronary angiogenesis and ischemic heart disease.冠状动脉血管生成和缺血性心脏病的新型分子靶点。
Coron Artery Dis. 2017 Nov;28(7):605-613. doi: 10.1097/MCA.0000000000000516.
7
Therapeutic angiogenesis revisited.再谈治疗性血管生成
Catheter Cardiovasc Interv. 2013 Nov 15;82(6):907-8. doi: 10.1002/ccd.25226.
8
Gene therapy for myocardial angiogenesis: has it come of age?心肌血管生成的基因治疗：它成熟了吗？
Curr Atheroscler Rep. 2000 Sep;2(5):373-9. doi: 10.1007/s11883-000-0075-3.
9
The emerging role of gene therapy in the treatment of cardiovascular diseases.基因治疗在心血管疾病治疗中的新兴作用。
Crit Rev Clin Lab Sci. 2003 Oct;40(5):499-545.
10
Gene therapy for atherosclerotic cardiovascular disease: a time for optimism and caution.动脉粥样硬化性心血管疾病的基因治疗：乐观与谨慎并存之时。
Mayo Clin Proc. 2000 Aug;75(8):831-4. doi: 10.4065/75.8.831.
引用本文的文献
1
Epsin bioactive coating reduced in-stent intimal hyperplasia by promoting early phase reendothelialization and inhibiting smooth muscle cell proliferation.埃普辛生物活性涂层通过促进早期再内皮化和抑制平滑肌细胞增殖，减少了支架内内膜增生。
PLoS One. 2025 Mar 25;20(3):e0318019. doi: 10.1371/journal.pone.0318019. eCollection 2025.
2
A small-diameter vascular graft immobilized peptides for capturing endothelial colony-forming cells.一种固定有肽以捕获内皮祖细胞的小直径血管移植物。
Front Bioeng Biotechnol. 2023 Apr 10;11:1154986. doi: 10.3389/fbioe.2023.1154986. eCollection 2023.
3
The grafts modified by heparinization and catalytic nitric oxide generation used for vascular implantation in rats.经肝素化和催化一氧化氮生成修饰的移植物用于大鼠血管植入。
Regen Biomater. 2018 Mar;5(2):105-114. doi: 10.1093/rb/rby003. Epub 2018 Mar 6.
4
Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo.组氨酸寡肽和靶向肽功能化的 TAT-NLS 用于增强细胞摄取并促进体内血管生成。
J Nanobiotechnology. 2018 Mar 26;16(1):29. doi: 10.1186/s12951-018-0358-x.
5
Drug- and Gene-eluting Stents for Preventing Coronary Restenosis.用于预防冠状动脉再狭窄的药物洗脱支架和基因洗脱支架。
Chonnam Med J. 2017 Jan;53(1):14-27. doi: 10.4068/cmj.2017.53.1.14. Epub 2017 Jan 25.
6
Electroporation-mediated delivery of a naked DNA plasmid expressing VEGF to the porcine heart enhances protein expression.电穿孔介导的血管内皮生长因子裸 DNA 质粒转染增强猪心蛋白表达。
Gene Ther. 2010 Mar;17(3):419-23. doi: 10.1038/gt.2009.153. Epub 2009 Dec 3.
7
In vitro and in vivo analysis of expression cassettes designed for vascular gene transfer.用于血管基因转移的表达盒的体外和体内分析。
Gene Ther. 2008 Mar;15(5):340-6. doi: 10.1038/sj.gt.3303058. Epub 2007 Nov 8.
8
Construction and characterization of a thrombin-resistant designer FGF-based collagen binding domain angiogen.一种抗凝血酶的基于成纤维细胞生长因子的胶原蛋白结合域血管生成素的构建与表征
Biomaterials. 2008 Jan;29(3):327-36. doi: 10.1016/j.biomaterials.2007.09.034. Epub 2007 Oct 22.
9
Delivery of large biopharmaceuticals from cardiovascular stents: a review.心血管支架中大型生物制药的递送：综述
Biomacromolecules. 2007 Nov;8(11):3281-93. doi: 10.1021/bm700540p. Epub 2007 Oct 12.
10
Radionuclide reporter gene imaging for cardiac gene therapy.用于心脏基因治疗的放射性核素报告基因成像
Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S27-33. doi: 10.1007/s00259-007-0438-x.
本文引用的文献
1
Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery.PREVENT III研究结果：一项关于依地福吉德预防下肢旁路手术中静脉移植物失败的多中心随机试验
J Vasc Surg. 2006 Apr;43(4):742-751; discussion 751. doi: 10.1016/j.jvs.2005.12.058.
2
Costameres, focal adhesions, and cardiomyocyte mechanotransduction.肌小节、黏着斑与心肌细胞机械转导
Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2291-301. doi: 10.1152/ajpheart.00749.2005.
3
Angiogenic gene-modified muscle cells for enhancement of tissue formation.用于增强组织形成的血管生成基因修饰肌肉细胞。
Tissue Eng. 2005 Jul-Aug;11(7-8):1034-44. doi: 10.1089/ten.2005.11.1034.
4
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.血管内皮生长因子-A、血管内皮生长因子-B、血管内皮生长因子-C和血管内皮生长因子-D的基因转移对高胆固醇血症低密度脂蛋白受体/载脂蛋白B48缺陷小鼠的动脉粥样硬化没有影响。
Circulation. 2005 Aug 30;112(9):1347-52. doi: 10.1161/CIRCULATIONAHA.105.534107.
5
Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients.紫杉醇洗脱支架或西罗莫司洗脱支架预防糖尿病患者再狭窄
N Engl J Med. 2005 Aug 18;353(7):663-70. doi: 10.1056/NEJMoa044372. Epub 2005 Aug 16.
6
Are your arteries older than your age?你的动脉比你的实际年龄更老吗？
Eur J Vasc Endovasc Surg. 2005 Dec;30(6):588-96. doi: 10.1016/j.ejvs.2005.06.011. Epub 2005 Aug 1.
7
GAPs in growth factor signalling.生长因子信号传导中的缺口
Growth Factors. 2005 Jun;23(2):143-9. doi: 10.1080/08977190500130480.
8
Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors--design, biosafety, and production.基因治疗的进展与前景：改进型慢病毒和逆转录病毒载体的发展——设计、生物安全性及生产
Gene Ther. 2005 Jul;12(14):1089-98. doi: 10.1038/sj.gt.3302570.
9
Role of the small heat shock proteins in regulating vascular smooth muscle tone.小热休克蛋白在调节血管平滑肌张力中的作用。
J Am Coll Surg. 2005 Jul;201(1):30-6. doi: 10.1016/j.jamcollsurg.2005.03.017.
10
Blood vessels engineered from human cells.由人类细胞构建的血管。
Lancet. 2005;365(9477):2122-4. doi: 10.1016/S0140-6736(05)66735-9.
Zotero 插件