Koole L H, Kruft M A, Aldenhoff Y B, van 't Oost N E, van Kroonenburgh M J, van der Veen F H
Centre for Biomaterials Research, University of Maastricht, The Netherlands.
Nat Biotechnol. 1998 Feb;16(2):172-6. doi: 10.1038/nbt0298-172.
A new polymeric biomaterial that contains covalently bound iodine, and is therefore radiopaque, was used to construct a sustained local drug-delivery device. A polymeric wall was designed to be porous (i.e., passage of low-molecular-weight molecules across the wall is possible), self-healing, and biocompatible. Once implanted, the sphere cavity can be filled and refilled with a concentrated solution of a (cytostatic) drug, which is subsequently released by slow diffusion into the tissue region surrounding the sphere. This principle of sustained local drug delivery is shown by a series of in vitro experiments on the release of 5-fluorouracil, and in vivo animal experiments, using x-ray fluoroscopic and scintigraphic techniques.
一种含有共价结合碘因而具有放射性不透明性的新型聚合物生物材料被用于构建一种持续局部给药装置。聚合物壁被设计成多孔的（即低分子量分子有可能穿过壁）、自愈合的且具有生物相容性。一旦植入，球腔可以用（细胞抑制剂）药物的浓缩溶液填充并重新填充，随后药物通过缓慢扩散释放到球周围的组织区域。5-氟尿嘧啶释放的一系列体外实验以及使用X射线荧光透视和闪烁成像技术的体内动物实验证明了这种持续局部给药的原理。
