Nakagawa Takayuki, Ito Juichi
Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Acta Otolaryngol Suppl. 2007 Feb(557):30-5. doi: 10.1080/03655230601065332.
Sensorineural hearing loss is one of the most common disabilities in our society. Experimentally, many candidates for therapeutic molecules have been discovered. However, the lack of safe and effective methods for drug delivery to the cochlea has been a considerable obstacle to clinical application. Local application of therapeutic molecules into the cochlea has been used in clinic and in animal experiments. Advances in pharmacological technology provide various drug delivery systems via biomaterials, which can be utilized for local drug delivery to the cochlea. Recent studies in the field of otology have demonstrated the potential of synthetic and natural biomaterials for local drug delivery to the cochlea. Although problems still remain to be resolved for clinical application, introduction into clinical practice of these controlled-release systems may be reasonable because of their certain advantages over previous methods.
感音神经性听力损失是我们社会中最常见的残疾之一。在实验中，已经发现了许多治疗性分子的候选物。然而，缺乏安全有效的药物递送至耳蜗的方法一直是临床应用的一个重大障碍。治疗性分子局部应用于耳蜗已用于临床和动物实验。药理学技术的进步通过生物材料提供了各种药物递送系统，可用于将药物局部递送至耳蜗。耳科学领域的最新研究已经证明了合成和天然生物材料用于将药物局部递送至耳蜗的潜力。尽管临床应用仍有问题有待解决，但由于这些控释系统相对于以前的方法具有一定优势，将它们引入临床实践可能是合理的。
