唾液酸：去除对培养心肌细胞钙交换性的影响。
Sialic acid: effect of removal on calcium exchangeability of cultured heart cells.
作者信息
Langer G A, Frank J S, Nudd L M, Seraydarian K
出版信息
Science. 1976 Sep 10;193(4257):1013-5. doi: 10.1126/science.948758.
PMID:948758
Abstract
Specific removal of sialic acid from cultured heart cells with purified neuraminidase increases cellular calcium exchangeability. Potassium exchange is unaffected or slightly decreased. Sialic acid removal also permits lanthanum, normally restricted to the cellular surface, to enter the cells and displace more than 80 percent of cellular calcium. The results indicate a specific role of cellular surface components in the control of calcium exchangeability in the heart.
摘要
用纯化的神经氨酸酶特异性去除培养的心脏细胞中的唾液酸可增加细胞钙交换能力。钾交换不受影响或略有下降。去除唾液酸还使通常局限于细胞表面的镧进入细胞，并取代超过80%的细胞钙。结果表明细胞表面成分在控制心脏钙交换能力中具有特定作用。
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