Krupienski M, Sparwasser C, Loy V, Kraft K, Pust R A
Abteilung Urologie, Bundeswehrkrankenhaus, Akademisches Krankenhaus, Universität Ulm.
Urologe A. 1997 Nov;36(6):557-60. doi: 10.1007/s001200050137.
The case of a 26 years old patient with a primary paraaortic extragonadal yolk sac tumor is presented. After operative reduction of the tumor polychemotherapy with PEB was performed. Following chemotherapy testicular biopsy did not show histological changes typical for testicular intraepithelial neoplasia (TIN). Three years after the initial manifestation of the yolk sac tumor, a malignant tumor of the testis with components of undifferentiated teratoma and yolk sac tumor was observed. In this paper the problems of development of testicular malignancy after polychemotherapy and the validity of a small exploratory excision of testicular tissue in retroperitoneal germ cell tumors and following chemotherapy are discussed.
本文报告了一例26岁原发性主动脉旁性腺外卵黄囊瘤患者的病例。肿瘤手术切除后，采用PEB方案进行了多药化疗。化疗后睾丸活检未显示睾丸上皮内瘤变（TIN）的典型组织学变化。卵黄囊瘤首次出现三年后，观察到一例睾丸恶性肿瘤，其具有未分化畸胎瘤和卵黄囊瘤成分。本文讨论了多药化疗后睾丸恶性肿瘤的发生问题，以及在腹膜后生殖细胞肿瘤和化疗后进行睾丸组织小范围探查性切除的有效性。
