Kovacević R, Radulovacki M
Science. 1976 Sep 10;193(4257):1025-7. doi: 10.1126/science.948760.
We have found that the metabolism of 5-hydroxytryptamine increases in the hippocampus and that the metabolism of dopamine decreases in the striatum and thalamus during slow-wave sleep, and we suggest that these changes are related to this stage of sleep. We have also found that the concentration of dopamine increases in the hippocampus during slow-wave sleep, and suggest that this may be related to the subsequent appearance of paradoxical sleep. These data raise new questions on the hippocampal role in the sleep-wakefulness cycle.
