González-Moles M A, Rodríguez-Archilla A, Ruiz-Avila I, González-Moles S, Marfil-Alvarez R
Departement of Oral Medicine, School of Dentistry, University of Granada, Spain.
Acta Stomatol Belg. 1996 Sep;93(3):113-8.
Several studies have established a probable relationship between HPV infections and oral neoplasia. The present study analyze the importance of the integration of DNA of HPV type 18 on the proliferative capability of oral squamous cell carcinoma (OSCC) by the study of PCNA expression. Thirty seven patients with OSCC were studied. A complete clinical history and histopathological study was performed. DNA of HPV-18 was found in 7 of the 37 oral OSCCs (19.1%). PCNA expression appeared in 75.7% of OSCCs (28 cases). 9 OSCCs (24.3%) were completely negative, whereas 13 (35.1%), 8 (21.6%) and 7 (18.9%) show minimal, moderate and intense PCNA expression. 4 HPV-18 positive OSCCs showed a intense PCNA expression, 1 OSCC showed moderate PCNA expression, whereas 2 OCSSs showed minimal PCNA expression. Statistical correlations between PCNA expression and DNA HPV-18 amplification showed a more intense PCNA expression in HPV-18 positive OSCCs (p = 0.023). Further studies are needed to establish whether the increase of cellular proliferation induced by HPV-18 has prognostic consequences.
多项研究已证实人乳头瘤病毒（HPV）感染与口腔肿瘤之间可能存在关联。本研究通过检测增殖细胞核抗原（PCNA）的表达，分析18型HPV DNA整合对口腔鳞状细胞癌（OSCC）增殖能力的影响。对37例OSCC患者进行研究，记录完整临床病史并开展组织病理学研究。37例口腔OSCC患者中，7例（19.1%）检测到18型HPV DNA。28例（75.7%）OSCC患者出现PCNA表达。9例（24.3%）OSCC患者PCNA表达完全阴性，13例（35.1%）、8例（21.6%）和7例（18.9%）分别呈低、中、高PCNA表达。4例18型HPV阳性OSCC患者呈高PCNA表达，1例呈中PCNA表达，2例呈低PCNA表达。PCNA表达与18型HPV DNA扩增之间的统计学相关性显示，18型HPV阳性OSCC患者PCNA表达更强（p = 0.023）。尚需进一步研究以确定18型HPV诱导的细胞增殖增加是否具有预后意义。
