新型隐球菌特异性抗体可改变人类白细胞细胞因子合成并促进T细胞增殖。
Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation.
作者信息
Vecchiarelli A, Retini C, Monari C, Casadevall A
机构信息
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
出版信息
Infect Immun. 1998 Mar;66(3):1244-7. doi: 10.1128/IAI.66.3.1244-1247.1998.
Abstract
Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.
摘要
将一种与新型隐球菌荚膜结合的单克隆抗体添加到人类单核细胞、T淋巴细胞和隐球菌细胞悬液中，（i）可增强白细胞介素-1β（IL-1β）、肿瘤坏死因子α和IL-2的产生；（ii）减少IL-10的分泌；（iii）促进T细胞增殖。特异性抗体影响细胞因子产生和淋巴细胞增殖的能力提示了一种体液免疫影响细胞介导免疫的机制。
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