新型隐球菌的纯化荚膜多糖可诱导人单核细胞分泌白细胞介素-10。
Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.
作者信息
Vecchiarelli A, Retini C, Monari C, Tascini C, Bistoni F, Kozel T R
机构信息
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
出版信息
Infect Immun. 1996 Jul;64(7):2846-9. doi: 10.1128/iai.64.7.2846-2849.1996.
Abstract
In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.
摘要
在本研究中，我们证明新型隐球菌的纯化荚膜多糖是人类单核细胞分泌白细胞介素-10（IL-10）的有效诱导剂。内源性IL-10参与调节人类单核细胞对包囊型新型隐球菌菌株产生反应时肿瘤坏死因子α和IL-1β的分泌。我们的结果提示葡糖醛酸木聚糖通过诱导IL-10（一种促炎细胞因子的有效下调因子）发挥新的免疫抑制作用。
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