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1
Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.新型隐球菌的纯化荚膜多糖可诱导人单核细胞分泌白细胞介素-10。
Infect Immun. 1996 Jul;64(7):2846-9. doi: 10.1128/iai.64.7.2846-2849.1996.
2
Capsular polysaccharide of Cryptococcus neoformans induces proinflammatory cytokine release by human neutrophils.新型隐球菌的荚膜多糖可诱导人中性粒细胞释放促炎细胞因子。
Infect Immun. 1996 Aug;64(8):2897-903. doi: 10.1128/iai.64.8.2897-2903.1996.
3
Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.新型隐球菌多糖对人单核细胞分泌肿瘤坏死因子α和白细胞介素-1β的下调作用。
Infect Immun. 1995 Aug;63(8):2919-23. doi: 10.1128/iai.63.8.2919-2923.1995.
4
Interdependency of interleukin-10 and interleukin-12 in regulation of T-cell differentiation and effector function of monocytes in response to stimulation with Cryptococcus neoformans.白细胞介素-10与白细胞介素-12在调节T细胞分化及单核细胞对新型隐球菌刺激的效应功能中的相互依赖性。
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Specific activated T cells regulate IL-12 production by human monocytes stimulated with Cryptococcus neoformans.特定活化的T细胞调节经新型隐球菌刺激的人单核细胞产生白细胞介素-12。
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6
Interleukin-12 counterbalances the deleterious effect of human immunodeficiency virus type 1 envelope glycoprotein gp120 on the immune response to Cryptococcus neoformans.
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Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.新型隐球菌成分刺激人单核细胞产生白细胞介素-6
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Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum.通过体外暴露于新型隐球菌和抗新型隐球菌抗血清诱导大鼠肺泡巨噬细胞中白细胞介素-6信使核糖核酸的产生。
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Infect Immun. 1997 Oct;65(10):4114-21. doi: 10.1128/iai.65.10.4114-4121.1997.

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Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model.葡聚糖醛酸木聚糖和甾基葡糖苷是动物疫苗接种模型中宿主保护所必需的。
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本文引用的文献

1
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.白细胞介素-10对人外周血单个核细胞针对新型隐球菌、白色念珠菌和脂多糖反应的影响。
Infect Immun. 1996 Mar;64(3):945-51. doi: 10.1128/iai.64.3.945-951.1996.
2
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.无症状的人类免疫缺陷病毒血清阳性个体中白细胞介素-2和白细胞介素-4产生的变化。
J Clin Invest. 1993 Mar;91(3):759-65. doi: 10.1172/JCI116294.
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Inhibition of candidacidal activity of polymorphonuclear cells by alveolar macrophage-derived factor from lung cancer patients.
Am Rev Respir Dis. 1993 Feb;147(2):414-9. doi: 10.1164/ajrccm/147.2.414.
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Role of human alveolar macrophages as antigen-presenting cells in Cryptococcus neoformans infection.人肺泡巨噬细胞作为新型隐球菌感染中抗原呈递细胞的作用。
Am J Respir Cell Mol Biol. 1994 Aug;11(2):130-7. doi: 10.1165/ajrcmb.11.2.8049074.
5
IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.白细胞介素-10抑制人外周血单个核细胞中细胞因子基因的转录。
J Immunol. 1994 Jul 15;153(2):811-6.
6
Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.新型隐球菌多糖对人单核细胞分泌肿瘤坏死因子α和白细胞介素-1β的下调作用。
Infect Immun. 1995 Aug;63(8):2919-23. doi: 10.1128/iai.63.8.2919-2923.1995.
7
Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A.新型隐球菌A血清型荚膜多糖的结构与抗原活性
Mol Immunol. 1980 Aug;17(8):1025-32. doi: 10.1016/0161-5890(80)90096-6.
8
Decreased virulence in stable, acapsular mutants of cryptococcus neoformans.新型隐球菌稳定无荚膜突变体的毒力降低。
Mycopathologia. 1982 Jul 23;79(1):23-9. doi: 10.1007/BF00636177.
9
Cryptococcal infections in patients with acquired immune deficiency syndrome.获得性免疫缺陷综合征患者的隐球菌感染
Am J Med. 1986 Jul;81(1):19-23. doi: 10.1016/0002-9343(86)90176-2.
10
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.白细胞介素10（IL-10）抑制人单核细胞的细胞因子合成：单核细胞产生的IL-10的自身调节作用。
J Exp Med. 1991 Nov 1;174(5):1209-20. doi: 10.1084/jem.174.5.1209.

新型隐球菌的纯化荚膜多糖可诱导人单核细胞分泌白细胞介素-10。

Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.

作者信息

Vecchiarelli A, Retini C, Monari C, Tascini C, Bistoni F, Kozel T R

机构信息

Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.

出版信息

Infect Immun. 1996 Jul;64(7):2846-9. doi: 10.1128/iai.64.7.2846-2849.1996.

DOI:10.1128/iai.64.7.2846-2849.1996
PMID:8698522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174153/
Abstract

In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.

摘要

在本研究中，我们证明新型隐球菌的纯化荚膜多糖是人类单核细胞分泌白细胞介素-10（IL-10）的有效诱导剂。内源性IL-10参与调节人类单核细胞对包囊型新型隐球菌菌株产生反应时肿瘤坏死因子α和IL-1β的分泌。我们的结果提示葡糖醛酸木聚糖通过诱导IL-10（一种促炎细胞因子的有效下调因子）发挥新的免疫抑制作用。