Burquier V, Koralnik I J, Vibert D, Burkhard P, Beaumanoir A, Jallon P, Mayer E, Hirschel B
Division des maladies infectieuses, hôpital cantonal universitaire, Genève, Suisse.
Neurophysiol Clin. 1997 Dec;27(6):508-19. doi: 10.1016/s0987-7053(97)82022-9.
Electrophysiologic tests may be abnormal in asymptomatic HIV-1-infected individuals. Our study was aimed at determining whether these findings have a prognostic value and could be corrected by antiviral treatment. In 18 patients, followed for 34 or 43 months, these findings were not progressive. Only one patient developed Aids dementia complex (ADC). Three have died (one with normal, two with abnormal tests at baseline). To study the effect of antiviral treatment, another group of seven asymptomatic patients was included into a cross-over double-blind study with either eight weeks zidovudine or eight weeks placebo, separated by eight more weeks without treatment. Electrophysiological evaluation was also performed in a group of 15 patients before antiviral therapy with zidovudine or didanosine was started and again after a mean of three and 13 months treatment. Results did not suggest that treatment reverses early electroencephalographic and otoneurological changes seen in HIV-1 infection.
在无症状的HIV-1感染个体中，电生理检查结果可能异常。我们的研究旨在确定这些发现是否具有预后价值，以及是否可通过抗病毒治疗得到纠正。对18例患者进行了34或43个月的随访，这些发现并无进展。仅1例患者发展为艾滋病痴呆综合征（ADC）。3例患者死亡（1例基线检查正常，2例基线检查异常）。为研究抗病毒治疗的效果，另一组7例无症状患者被纳入一项交叉双盲研究，分别接受为期8周的齐多夫定或8周的安慰剂治疗，中间间隔8周不进行治疗。在一组15例患者开始使用齐多夫定或去羟肌苷进行抗病毒治疗前以及平均治疗3个月和13个月后，也进行了电生理评估。结果并不表明治疗能逆转HIV-1感染早期出现的脑电图和耳神经学变化。
