Wuyts B, Delanghe J, De Buyzere M
Central Laboratory, University Hospital Gent, Belgium.
Acta Clin Belg. 1997;52(6):338-49. doi: 10.1080/17843286.1997.11718599.
Since the identification of an Insertion/Deletion polymorphism in the ACE gene, numerous studies have evaluated the potential risk of the DD genotype in cardiovascular disease and hypertension. The report of many conflicting publications reveals a strong need for reviewing the most important data. There is evidence of the absence of an association between the ACE polymorphism and hypertension in Caucasians. In blacks a positive association between the D allele and high blood pressure was seen, Japanese studies show discrepant results. Several studies showed no association between the ACE polymorphism and the risk of myocardial infarction. However, in certain subpopulations, such as low risk patients or coronary care unit patients, an increased risk of myocardial infarction in DD type is present, and a meta-analysis supports this proposition. Because of conflicting data, the potential association between the ACE polymorphism and coronary artery disease, cerebrovascular disease, left ventricular hypertrophy, hypertrophic and idiopathic dilated cardiomyopathy, carotid artery disease and diabetic and immunoglobin A nephropathy, remains inconclusive.
自从在血管紧张素转换酶（ACE）基因中发现插入/缺失多态性以来，众多研究评估了DD基因型在心血管疾病和高血压方面的潜在风险。许多相互矛盾的出版物报告表明，迫切需要对最重要的数据进行综述。有证据表明，在白种人中，ACE多态性与高血压之间不存在关联。在黑人中，发现D等位基因与高血压呈正相关，而日本的研究结果则不一致。几项研究表明，ACE多态性与心肌梗死风险之间没有关联。然而，在某些亚人群中，如低风险患者或冠心病监护病房患者，DD型心肌梗死风险增加，一项荟萃分析支持这一观点。由于数据相互矛盾，ACE多态性与冠状动脉疾病、脑血管疾病、左心室肥厚、肥厚性和特发性扩张型心肌病、颈动脉疾病以及糖尿病和免疫球蛋白A肾病之间的潜在关联仍无定论。
