Santoro V, Pozzuoli M L, Colella G
Istituto di Chirurgia Orale e Maxillo Facciale, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi, Napoli.
Minerva Stomatol. 1997 Nov;46(11):595-601.
The authors review the literature on the role of human papilloma virus in premalignant and malignant oral tumours. They describe the biomolecular mechanisms of action and report the data of other authors regarding the incidence of the DNA of HPV in both normal mucosa of healthy subjects and in patients affected by disease, in tissues taken from benign and malignant lesions of the oral cavity. Having commented on these findings, they discuss the possible interference of analysis techniques, various kits and clinical conditions may have on the final results.
作者回顾了关于人乳头瘤病毒在口腔癌前病变和恶性肿瘤中作用的文献。他们描述了其生物分子作用机制,并报告了其他作者关于在健康受试者的正常黏膜以及患有口腔疾病的患者中,取自口腔良性和恶性病变组织的人乳头瘤病毒DNA发生率的数据。在对这些发现进行评论后,他们讨论了分析技术、各种试剂盒以及临床状况可能对最终结果产生的干扰。