Hua S E, Lenz F A, Zirh T A, Reich S G, Dougherty P M
Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.
J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):273-6. doi: 10.1136/jnnp.64.2.273.
Animal studies suggest that an olivocerebello-bulbospinal pathway mediates harmaline induced tremor, which resembles essential tremor in humans. However, recent evidence suggests that thalamocortical pathways participate in essential tremor. Thalamic single neuron activity has been analysed during thalamotomy for essential tremor. It has been shown by spectral cross correlation analysis that thalamic activity has a significant, linear relation to forearm EMG activity during tremor. The presence of this tremor related activity at the site where a lesion abolishes essential tremor suggests that the thalamus has an important role in the mechanism of essential tremor.
动物研究表明，橄榄小脑-延髓脊髓通路介导了harmaline诱导的震颤，这种震颤类似于人类的特发性震颤。然而，最近的证据表明丘脑皮质通路参与了特发性震颤。在进行丘脑切开术治疗特发性震颤期间，对丘脑单个神经元活动进行了分析。通过频谱互相关分析表明，在震颤期间，丘脑活动与前臂肌电图活动存在显著的线性关系。在损伤可消除特发性震颤的部位存在这种与震颤相关的活动，这表明丘脑在特发性震颤的机制中具有重要作用。
