[Electron microscopic study of the kinetics of smallpox vaccine interaction with alveolar macrophages when administered intratracheally].

Electron microscopy was applied to the study of the dynamics of endocytosis of smallpox vaccine by alveolar macrophages in intratracheal immunization of guinea pigs; 5 to 15 minutes after administration of smallpox vaccine the viruses were absorbed on the macrophage surface, penetrated into the cells by invagination and vesiculation. A possibility of adaption of smallpox virus in the alveolar macrophages 12 hours after the vaccination was confirmed documentally.