多发性骨髓瘤自体血细胞移植3个月后发生浆细胞白血病。
Plasma cell leukemia 3 months after autologous blood cell transplantation for multiple myeloma.
作者信息
Koskela K, Pelliniemi T T, Lakkala T, Remes K
机构信息
Department of Medicine, Turku University Central Hospital, MediCity Research Center, Finland.
出版信息
Bone Marrow Transplant. 1998 Feb;21(3):305-7. doi: 10.1038/sj.bmt.1701080.
PMID:9489657
Abstract
We describe a patient with multiple myeloma who was treated with intensive therapy and autologous blood cell transplantation as her first-line treatment. The disease relapsed 3 months after the transplant as plasma cell leukemia and the patient succumbed in 4 weeks. We suggest that an aggressive plasma cell clone may be selected during the course of intensive treatment. Complex karyotypic findings are also presented.
摘要
我们描述了一名多发性骨髓瘤患者，其一线治疗采用强化疗法和自体血细胞移植。移植后3个月疾病复发为浆细胞白血病，患者在4周内死亡。我们认为在强化治疗过程中可能选择了具有侵袭性的浆细胞克隆。文中还展示了复杂的核型结果。
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