Schultz-Coulon H J, Eckermeier L
Acta Otolaryngol. 1976 Jul-Aug;82(1-2):131-42.
Up to now little is known about the anatomy and histology and especially about the germinative zones of the growing nasal septum. We totally removed 18 septa of children between 0 and 10 years immediately after death. After photographical documentation these septa were studied histologically and microadiographically. It was found that at birth the connection between the cartilaginous septum and vomer only consists of a small and very loose layer of connective tissues. During the first year of life several ossification areas appear between vomer and cartilage in the dorsal part of the septum. An enchondral ossification zone at the rostrum sphenoidale was regularly seen in the neonatal septum, but disappears soon after birth. The development of the perpendicular plate starts from multiple ossification centersregularlytobefoundinthedorso-cranialpartoftheneonatalseptum. The perpendicular plate is the fastest growing part of the septum and even in the tenth year of life still shows an enchondral ossification zone around its border. The shape and the size ofthe septum changes most during the first six years; subsequently septal growth slows down markedly. As the enchondral ossification zone resembles an epiphysis cartilage, it is assumed thatlesions in this area may lead to growth disturbances of the inner and outer nose. It is therefore emphasized that, rgarding rhinoplasty in children, this ossification zone should be preserved by the surgeon.
到目前为止，对于生长中的鼻中隔的解剖学和组织学，尤其是生发区，人们了解甚少。我们在儿童死亡后立即完整切除了18例0至10岁儿童的鼻中隔。在进行摄影记录后，对这些鼻中隔进行了组织学和显微放射学研究。结果发现，出生时软骨鼻中隔与犁骨之间的连接仅由一小层非常疏松的结缔组织构成。在生命的第一年，鼻中隔背侧的犁骨与软骨之间出现了几个骨化区域。在新生儿鼻中隔的蝶骨嵴处经常可见软骨内骨化区，但出生后不久就消失了。垂直板的发育始于多个骨化中心，这些骨化中心通常位于新生儿鼻中隔的背颅部。垂直板是鼻中隔生长最快的部分，即使在生命的第十年，其边缘仍显示有软骨内骨化区。鼻中隔的形状和大小在头六年变化最大；随后鼻中隔生长明显减缓。由于软骨内骨化区类似于骨骺软骨，因此推测该区域的病变可能导致鼻内外的生长紊乱。因此强调，对于儿童鼻整形术，外科医生应保留这个骨化区。
