Picco P, Gattorno M, Buoncompagni A, Facchetti P, Rossi G, Pistoia V
2nd Division of Pediatrics, Giannina Gaslini Scientific Institute, Genoa, Italy.
J Rheumatol. 1998 Feb;25(2):347-51.
To evaluate prolactin (PRL) serum levels in prepubertal girls affected with 2 different subtypes of pauciarticular onset juvenile chronic arthritis (JCA) and with previous acute postinfectious arthritis in remission (AA), and to correlate the relationship of PRL versus interleukin 6 (IL-6) serum levels.
Eleven girls with antinuclear antibody (ANA) positive early onset pauciarticular JCA, 8 with ANA negative late onset pauciarticular JCA of various forms (considered to have spondyloarthropathy, SpA), and 7 who had had AA were evaluated for serum concentrations of PRL, IL-6, and thyroid hormones and presence of uveitis. All were prepubertal and without clinical or biological signs of disease activity.
Mean serum concentrations of PRL were significantly increased in ANA positive (8.9 +/- 4.0 ng/ml) patients and in patients with SpA (7.8 +/- 2.4 ng/ml) compared to those of AA patients (4.4 +/- 0.3 ng/ml) (p = 0.01 and p = 0.025, respectively) and to controls. Both ANA positive and SpA patients showed increased mean serum concentrations of IL-6 in comparison with AA patients and controls. Significant correlation between PRL and IL-6 concentrations (r = 0.604, p = 0.002) was observed from the whole series.
We found a direct correlation between serum levels of PRL and IL-6 in both ANA positive JCA patients and in ANA negative SpA patients; thus, hyperprolactinemia correlates better with the chronic course of the disease than with ANA positivity.
评估患有两种不同亚型少关节型幼年慢性关节炎（JCA）且既往有急性感染后关节炎已缓解（AA）的青春期前女孩的血清催乳素（PRL）水平，并探讨PRL与白细胞介素6（IL-6）血清水平之间的关系。
对11例抗核抗体（ANA）阳性的早发型少关节型JCA女孩、8例ANA阴性的各种类型晚发型少关节型JCA（被认为患有脊柱关节病，SpA）女孩以及7例曾患AA的女孩进行评估，检测其血清PRL、IL-6和甲状腺激素浓度以及葡萄膜炎的情况。所有患者均为青春期前，且无疾病活动的临床或生物学体征。
与AA患者（4.4±0.3 ng/ml）相比，ANA阳性患者（8.9±4.0 ng/ml）和SpA患者（7.8±2.4 ng/ml）的PRL平均血清浓度显著升高（分别为p = 0.01和p = 0.025），且高于对照组。与AA患者及对照组相比，ANA阳性和SpA患者的IL-6平均血清浓度均升高。从整个系列中观察到PRL与IL-6浓度之间存在显著相关性（r = 0.604，p = 0.002）。
我们发现ANA阳性JCA患者和ANA阴性SpA患者的血清PRL水平与IL-6水平之间存在直接相关性；因此，高催乳素血症与疾病的慢性病程相关性更好，而非与ANA阳性相关。
