Keul R, Heinrich P C, Müller-newen G, Muller K, Woo P
Department of Biochemistry, Klinikum Pauwelsstrasse 30, D-52057 Aachen, Germany.
Cytokine. 1998 Sep;10(9):729-34. doi: 10.1006/cyto.1997.0343.
Investigation of the agonist and two antagonists to interleukin 6 (IL-6) and their possible role in the pathogenesis of different sub-groups of juvenile chronic arthritis (JCA). Sera of 54 patients and 10 age-matched controls were tested: 20 with pauci-articular JCA, 12 with polyarticular JCA, and 22 systemic JCA. Interleukin 6, soluble interleukin 6 receptor (agonist), soluble gp130 and autoantibodies to IL-6 (antagonist to IL-6) were measured, as well as C-reactive protein as an indicator of disease activity. In addition, during fever two systemic JCA patients were analysed longitudinally for these parameters. There was a significant increase in soluble IL-6 receptor (sIL-6R) concentrations. No difference in the levels of soluble gp130 and autoantibodies to IL-6 in the systemic JCA group was found. In two patients the fever curves corresponded to the IL-6 levels measured. sIL-6R serum concentrations also showed a tendency to follow the fever. The authors have shown that in systemic JCA, the levels of sIL-6R, agonist of IL-6, were increased significantly compared to the other groups, while levels of antagonists to IL-6 were not changed in the face of increased levels of IL-6 in systemic JCA. These results suggest an imbalance of IL-6 homeostasis.
对白介素6（IL-6）的一种激动剂和两种拮抗剂及其在青少年慢性关节炎（JCA）不同亚组发病机制中可能作用的研究。检测了54例患者和10例年龄匹配对照的血清：20例少关节型JCA患者、12例多关节型JCA患者和22例全身型JCA患者。检测了白介素6、可溶性白介素6受体（激动剂）、可溶性gp130以及抗IL-6自身抗体（IL-6拮抗剂），并将C反应蛋白作为疾病活动的指标。此外，在发热期间对2例全身型JCA患者的这些参数进行了纵向分析。可溶性IL-6受体（sIL-6R）浓度显著升高。全身型JCA组中可溶性gp130和抗IL-6自身抗体水平未发现差异。在2例患者中，发热曲线与所测的IL-6水平相符。sIL-6R血清浓度也显示出随发热而变化的趋势。作者表明，在全身型JCA中，与其他组相比，IL-6激动剂sIL-6R的水平显著升高，而在全身型JCA中IL-6水平升高的情况下，IL-6拮抗剂的水平并未改变。这些结果提示IL-6稳态失衡。
