Dierickx P J
Instituut voor Volksgezondheid, Afdeling Toxikologie, Brussel, Belgium.
FEBS Lett. 1998 Jan 30;422(2):185-8. doi: 10.1016/s0014-5793(98)00006-4.
Protection against xenobiotic insult, including cancer chemoprotection, can be achieved by a variety of natural and synthetic compounds belonging to over 20 different classes of chemicals. They all induce or activate drug-metabolizing enzymes. The discovery of a new class of activator is currently reported. Sodium fluoride activated the phase I ethoxyresorufin-O-deethylase (to 240%) and pentoxyresorufin-O-depentylase (to 156%), and the phase II glutathione transferase to 120% of the basal activities in rat hepatoma-derived Fa32 cells. It is, therefore, a bifunctional enzyme activator. A time- and concentration-dependent activation was observed. A possible impact of the daily fluoride uptake from drinking water is suggested.
对异源生物损伤的防护，包括癌症化学预防，可以通过属于20多种不同化学类别的各种天然和合成化合物来实现。它们都能诱导或激活药物代谢酶。目前报道了一类新的激活剂。氟化钠激活了大鼠肝癌衍生的Fa32细胞中的I相乙氧基试卤灵-O-脱乙基酶（至基础活性的240%）和戊氧基试卤灵-O-脱戊基酶（至基础活性的156%），以及II相谷胱甘肽转移酶至基础活性的120%。因此，它是一种双功能酶激活剂。观察到了时间和浓度依赖性激活。提示了从饮用水中每日摄取氟的可能影响。
