Spieker L E, Binggeli C, Lüscher T F, Noll G
Universitätsspital Zürich.
Schweiz Med Wochenschr. 1997 Nov 29;127(48):1986-92.
The sympathetic nervous system is an important regulator of the circulation. Interactions with other regulating systems, e.g. the renin angiotensin system, play important roles. By means of microneurography, sympathetic activity in humans can be assessed directly in the nerve. Insights into the dynamic regulation of the circulation under physiological and pathophysiological conditions are possible. Activation of the sympathetic nervous system in cardiovascular diseases affects course, prognosis, and therapy. Prognosis in heart failure depends on sympathetic activation, which can be decreased by inhibition of angiotensin II synthesis by ACE-inhibitors. In contrast to nitrates, these drugs do not increase sympathetic activity. The sympathetic nervous system is also heavily involved in the pathogenesis of hypertension. Borderline hypertensives and offspring of hypertensive parents show increased sympathetic nerve activities. Investigation of the sympathetic nervous system under physiological and pathophysiological conditions may serve as a basis for new therapeutic strategies.
交感神经系统是循环系统的重要调节者。它与其他调节系统（如肾素-血管紧张素系统）的相互作用起着重要作用。通过微神经ography术，可以直接在神经中评估人体的交感神经活动。从而有可能深入了解生理和病理生理条件下循环系统的动态调节。心血管疾病中交感神经系统的激活会影响病程、预后和治疗。心力衰竭的预后取决于交感神经激活，而通过ACE抑制剂抑制血管紧张素II的合成可以降低这种激活。与硝酸盐不同，这些药物不会增加交感神经活动。交感神经系统也大量参与高血压的发病机制。临界高血压患者和高血压患者的后代表现出交感神经活动增加。在生理和病理生理条件下对交感神经系统的研究可能为新的治疗策略提供依据。
