Pogodina O N, Karaseva N A, Ivanov V A
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Tsitologiia. 1997;39(7):582-9.
The cytotoxic activity of peripheral blood lymphocytes of 135 lung cancer patients was studied. A wide range of cytotoxicity values was shown--from 0 to 88%. During the randomized investigation of these patients no strong correlation was found between the levels of cytotoxicity and the cancer stages. A certain tendency of increasing the number of patients with weak cytotoxic activity upon progressing disease was followed. The lymphocytes with a strong natural killer activity did not react on the in vitro incubation with interleukin-2. The lymphocytes with a strong was obtained when the lymphocytes with the lowest cytotoxicity levels were incubated with this immunomodulator.
对135例肺癌患者外周血淋巴细胞的细胞毒性活性进行了研究。结果显示细胞毒性值范围很广——从0到88%。在对这些患者进行随机调查期间，未发现细胞毒性水平与癌症分期之间有很强的相关性。随着疾病进展，细胞毒性活性较弱的患者数量有一定增加趋势。具有强自然杀伤活性的淋巴细胞在与白细胞介素-2体外孵育时无反应。当细胞毒性水平最低的淋巴细胞与这种免疫调节剂孵育时，可获得具有强[此处原文似乎有误，推测可能是“活性”之类，结合前文]的淋巴细胞。
