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[从L-鼠李醛合成三萜2,6-二脱氧-α-L-阿拉伯己吡喃糖苷及其药理性质]

[Synthesis of triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides from L-rhamnal. Their pharmacological properties].

作者信息

Baltina L A, Flekhter O B, Davydova V A, Ismagilova A F, Zarudiĭ F S, Nasyrov Kh M, Gromakova L S, Tolstikov G A

出版信息

Bioorg Khim. 1997 Oct;23(10):826-31.

PMID:9490620
Abstract

Triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides were synthesized by the glycosylation of oleanane triterpene alcohols with L-rhamnal acetate in the presence of cationite KU-2-8 and lithium bromide. 2,6-Dideoxy-alpha-L-arabino-hexopyranosides of allobetulin and methyl glycyrrhetinate showed pronounced antiulcerous activity; the latter also stimulated reparative skin regeneration in rats and was effective as a hepatoprotectant.

摘要

通过在阳离子交换剂KU-2-8和溴化锂存在下,将齐墩果烷三萜醇与乙酸L-鼠李糖进行糖基化反应,合成了三萜2,6-二脱氧-α-L-阿拉伯己吡喃糖苷。白桦脂醇和甘草次酸甲酯的2,6-二脱氧-α-L-阿拉伯己吡喃糖苷具有显著的抗溃疡活性;后者还能刺激大鼠皮肤的修复性再生,并且作为一种肝保护剂有效。

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