Hagenau W, Pietsch D, Arndt J O
Anaesthesist. 1976 Jul;25(7):331-41.
The effect of halothane, enflurane, propanidid and ketamine on the sensitivity of the aortic baroreceptors and its quantitative relationship with arterial pressure were studied in decerebrated cats. Receptor response curves (single baroreceptor fibres of the depressor nerve) were constructed by plotting the average discharge rate (spikes/sec) against the aortic mean pressure and the effect of the anaesthetics on them was analysed. The blood pressure was changed over wide ranges by inflating a balloon placed in the thoracic part of the descending aorta through a femoral artery. Receptor sensitivity increased with halothane and enflurane, yet it decreased with propanidid. It remained uneffected duringanesthesia with ketamine. Thus, different anesthetics act differently on the afferent impulse traffic of baroreceptors. The possible role of these effects on blood pressure control during anaesthesia is discussed.
在去大脑猫身上研究了氟烷、恩氟烷、丙泮尼地和氯胺酮对主动脉压力感受器敏感性的影响及其与动脉血压的定量关系。通过绘制平均放电频率（脉冲/秒）与主动脉平均压力的关系曲线，构建了受体反应曲线（减压神经的单根压力感受器纤维），并分析了麻醉剂对其的影响。通过经股动脉向置于降主动脉胸段的气囊充气，在很宽的范围内改变血压。氟烷和恩氟烷使受体敏感性增加，而丙泮尼地使其降低。氯胺酮麻醉期间受体敏感性无变化。因此，不同的麻醉剂对压力感受器的传入冲动活动有不同的作用。文中讨论了这些作用在麻醉期间对血压控制的可能影响。
