Kenner J R, Benson P M, Sinha C, Willard C C, Harrington A C, Sau P
Dermatology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
Dermatol Surg. 1998 Feb;24(2):283-5. doi: 10.1111/j.1524-4725.1998.tb04150.x.
Acinic cell carcinoma (ACC) is a rare tumor generally involving the parotid gland and infrequently the minor salivary glands.
Clinical and histopathological characteristics of a case of ACC of the minor salivary glands, and brief review of the literature.
Routine stains with H&E, PAS, iron, and mucicarmine; immunohistochemistry with cytokeratin, CEA, S-100, and leu-M1.
The ACC was removed by wide local excision. Histopathology revealed papillary cystic, solid, and ductal architectural features. The mucinous material within the lumina of the cystic and ductal structures was PAS and mucicarmine positive, and diastase resistant. All tested immunohistochemical reagents reacted with the epithelial cells. There were no mitoses, necrosis, cellular pleomorphism, or infiltration.
ACC is a rare tumor of salivary glands characterized by an indolent clinical course with the potential for both local recurrence and metastatic spread when tracked for decades. Published mortality rates vary from 6 to 50%. Histopathologic features do not reliably predict biologic behavior.
腺泡细胞癌（ACC）是一种罕见肿瘤，通常累及腮腺，很少累及小唾液腺。
报告1例小唾液腺ACC的临床和组织病理学特征，并对文献进行简要回顾。
采用苏木精-伊红（H&E）、过碘酸雪夫（PAS）、铁染色和黏液卡红进行常规染色；采用细胞角蛋白、癌胚抗原（CEA）、S-100和白细胞共同抗原（leu-M1）进行免疫组织化学染色。
通过广泛局部切除将ACC切除。组织病理学显示有乳头状囊性、实性和导管结构特征。囊性和导管结构管腔内的黏液物质PAS和黏液卡红染色呈阳性，且耐淀粉酶消化。所有检测的免疫组织化学试剂均与上皮细胞发生反应。未见有丝分裂、坏死、细胞多形性或浸润。
ACC是一种罕见的唾液腺肿瘤，其临床病程较为惰性，但随访数十年时有局部复发和转移扩散的可能。已发表的死亡率从6%到50%不等。组织病理学特征不能可靠地预测生物学行为。
