Niessen W M
Hyphen Mass Spectrometry Consultancy, Leiden, The Netherlands.
J Chromatogr A. 1998 Jan 23;794(1-2):407-35. doi: 10.1016/s0021-9673(97)01112-6.
In the past few years, the instrumental developments in the field of combined liquid chromatography-mass spectrometry (LC-MS) and related liquid-introduction techniques has been extremely fast. Soon after the demonstration of the ability to obtain multiply-charged ions from proteins by electrospray ionization, a major impetus was given to the field. Numerous LC-MS systems based on atmospheric-pressure ionization sources have now been described. This paper reviews these instrumental developments with reference to currently available commercial LC-MS systems. Not only low and high flow-rate electrospray on quadrupole instrument is discussed, but also electrospray on ion-trap, double-focusing sector, time-of-flight, and Fourier-transform ion-cyclotron resonance instruments are reviewed.
在过去几年中，液相色谱 - 质谱联用（LC-MS）领域以及相关液体引入技术的仪器发展极为迅速。在通过电喷雾电离从蛋白质中获得多电荷离子的能力得到证明后不久，该领域便获得了巨大的推动力。现在已经描述了许多基于大气压电离源的LC-MS系统。本文参考当前可用的商用LC-MS系统回顾了这些仪器的发展情况。不仅讨论了四极杆仪器上的低流速和高流速电喷雾，还回顾了离子阱、双聚焦扇形磁场、飞行时间和傅里叶变换离子回旋共振仪器上的电喷雾。
