血管紧张素转换酶抑制剂的体外抗氧化能力
Antioxidant power of angiotensin-converting enzyme inhibitors in vitro.
作者信息
Benzie I F, Tomlinson B
机构信息
Department of Nursing & Health Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon.
出版信息
Br J Clin Pharmacol. 1998 Feb;45(2):168-9. doi: 10.1046/j.1365-2125.1998.00664.x.
Abstract
AIMS
There is controversy regarding the potential antioxidant effect of captopril, therefore this study was performed to compare the in vitro antioxidant power of captopril with other angiotensin-converting enzyme (ACE) inhibitors.
METHODS
Antioxidant power of captopril, enalapril, fosinopril, perindopril, quinapril and ramipril in aqueous solution was measured using the ferric reducing (antioxidant) power (FRAP) assay; captopril was also measured in ethanolic solution.
RESULTS
Only captopril showed significant antioxidant power, demonstrating a stoichiometric factor of 1.0 in this assay. Concentration-related antioxidant power was seen in both aqueous and ethanolic solutions.
CONCLUSIONS
Captopril shows antioxidant activity in vitro. This property could be relevant in vivo if captopril is concentrated in membranes, lipoproteins or at other important sites.
摘要
目的
关于卡托普利的潜在抗氧化作用存在争议，因此进行本研究以比较卡托普利与其他血管紧张素转换酶（ACE）抑制剂的体外抗氧化能力。
方法
使用铁还原（抗氧化）能力（FRAP）测定法测量卡托普利、依那普利、福辛普利、培哚普利、喹那普利和雷米普利在水溶液中的抗氧化能力；卡托普利也在乙醇溶液中进行了测量。
结果
仅卡托普利显示出显著的抗氧化能力，在该测定中显示化学计量系数为1.0。在水溶液和乙醇溶液中均观察到与浓度相关的抗氧化能力。
结论
卡托普利在体外显示出抗氧化活性。如果卡托普利集中在细胞膜、脂蛋白或其他重要部位，该特性在体内可能具有相关性。
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Captopril has no significant scavenging antioxidant activity in human plasma in vitro or in vivo.卡托普利在体外或体内的人体血浆中均无显著的清除抗氧化活性。
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Captopril has no significant scavenging antioxidant activity in human plasma in vitro or in vivo.卡托普利在体外或体内的人体血浆中均无显著的清除抗氧化活性。
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