Chopra M, Scott N, McMurray J, McLay J, Bridges A, Smith W E, Belch J J
University Departments of Medicine and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee.
Br J Clin Pharmacol. 1989 Mar;27(3):396-9. doi: 10.1111/j.1365-2125.1989.tb05384.x.
The use of captopril in heart failure and hypertension is becoming increasingly accepted. Captopril has a sulphydryl group in its molecular structure. We wondered if this might confer free radical scavenging activity on the drug and have investigated this in an in vitro system. Results show that captopril is a free radical scavenger and we suggest that this action might be relevant in its use in heart failure and other vascular diseases.
卡托普利在心力衰竭和高血压治疗中的应用越来越被认可。卡托普利的分子结构中有一个巯基。我们想知道这是否会赋予该药物自由基清除活性，并在体外系统中对此进行了研究。结果表明卡托普利是一种自由基清除剂，我们认为这一作用可能与其在心力衰竭和其他血管疾病中的应用有关。
