Olive D
Arch Fr Pediatr. 1976 Jun-Jul;33(6):607-20.
First, chemotherapy was used to reduce metastatic tumours. Then, instead of a limited number of antimitotic agents, it permited to increase both the number of complete remissions and the survival ratio, mostly in embryonal tumours and lymphomas. The essential purpose of chemotherapy is to kill occult metastases. Combination chemotherapy using many agents with differing modes of action took place of monochemotherapy. In sophisticated schedules, drugs are given intermittently, to synchronizing treatment with the tumour doubling time and the recovery of normal rapidly dividing tissues. Unhappily, its use remains empiric, according to uncertainty about tumoral cell kinetic and modes of drugs action. Immediate toxicity of aggressive schedules prescribe to realize them in specialized pediatric centres. At last, in the future, it will not be enough to cure infantile cancer, but to allow children to live with less sequelae than to day.
首先，化疗被用于缩小转移性肿瘤。然后，与使用有限数量的抗有丝分裂药物不同，它能够提高完全缓解率和生存率，这在胚胎性肿瘤和淋巴瘤中最为明显。化疗的主要目的是杀死隐匿性转移灶。联合使用多种作用方式不同的药物进行化疗取代了单一化疗。在复杂的化疗方案中，药物间歇性给药，以使治疗与肿瘤倍增时间以及正常快速分裂组织的恢复同步。不幸的是，由于肿瘤细胞动力学和药物作用方式存在不确定性，化疗的使用仍然是经验性的。激进化疗方案的即时毒性要求在专门的儿科中心实施。最后，在未来，治愈儿童癌症将不仅仅是足够的，还需要让儿童比现在留下更少的后遗症地生活。
