Barnes S
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 35294, USA.
Proc Soc Exp Biol Med. 1998 Mar;217(3):386-92. doi: 10.3181/00379727-217-44249.
Soy is a unique dietary source of the isoflavones, genistein and daidzein. It has been part of the Southeast Asian diet for nearly five millenia, whereas consumption of soy in the United States and Western Europe has been limited to the 20th century. Heavy consumption of soy in Southeast Asian populations is associated with reduction in the rates of certain cancers and cardiovascular disease. Recent experimental evidence suggests that phytochemicals in soy are responsible for its beneficial effects, which may also include prevention of osteoporosis, a hereditary chronic nose bleed syndrome, and autoimmune diseases. Exposure of soy formula-fed infants to the potential estrogenizing effects of the isoflavones is limited by the first pass effect of the liver following the uptake of isoflavones from the gut. Several mechanisms of action of isoflavones have been proposed-both through estrogen-dependent and estrogen-independent pathways.
大豆是异黄酮、染料木黄酮和大豆苷元的独特膳食来源。在近五千年的时间里，它一直是东南亚饮食的一部分，而在美国和西欧，大豆的消费直到20世纪才开始。东南亚人群大量食用大豆与某些癌症和心血管疾病发病率的降低有关。最近的实验证据表明，大豆中的植物化学物质是其有益作用的原因，这些有益作用可能还包括预防骨质疏松症、一种遗传性慢性鼻出血综合征和自身免疫性疾病。食用大豆配方奶粉的婴儿接触异黄酮潜在的雌激素化作用会受到肝脏在从肠道摄取异黄酮后的首过效应的限制。已经提出了异黄酮的几种作用机制——通过雌激素依赖性和雌激素非依赖性途径。
