Corlette M B, Mendes-Monteroi A C, Bismuth H, Morin J
Arch Surg. 1976 Sep;111(9):1017-20. doi: 10.1001/archsurg.1976.01360270089017.
The immediate evolution of changes in serum bilirubin and alkaline phosphatase levels during and after brief temporary occlusion (12 hours or less) of the main bile duct was studied in the rat. Transient obstruction of the main bile duct of more than one hour was characterized by a simultaneous increase in serum levels of both bilirubin and alkaline phosphatase. The time required for return to normal values was less for bilirubin than the duration of a brief obstruction and was more prolonged for alkaline phosphatase than the duration of obstruction. In obstruction of four or more hours, it was rare to find an isolated elevation of serum bilirubin; this occurred when the control value for alkaline phosphatase levels was low and their relative increase was obscured. Thus, an isolated increase in the serum bilirubin level is infrequently compatible with obstruction of the bile duct, even when transient and of brief duration. Conversely, isolated elevation of serum alkaline phosphatase levels in an acute abdominal syndrome may indicate relieved biliary obstruction.
在大鼠中研究了主胆管短暂临时阻塞（12小时或更短时间）期间及之后血清胆红素和碱性磷酸酶水平变化的即时演变情况。主胆管超过1小时的短暂阻塞表现为血清胆红素和碱性磷酸酶水平同时升高。胆红素恢复至正常水平所需时间比短暂阻塞的持续时间短，而碱性磷酸酶恢复至正常水平所需时间比阻塞持续时间长。在阻塞4小时或更长时间时，很少发现血清胆红素单独升高；当碱性磷酸酶水平的对照值较低且其相对升高不明显时会出现这种情况。因此，即使是短暂的胆管阻塞，血清胆红素水平单独升高也很少与胆管阻塞相符。相反，急性腹部综合征中血清碱性磷酸酶水平单独升高可能表明胆管阻塞已缓解。
