Holmberg J T, Hultberg B, Ihse I, Isaksson A
Scand J Gastroenterol. 1985 Sep;20(7):868-72. doi: 10.3109/00365528509088837.
Plasma levels of the lysosomal enzymes beta-glucuronidase and beta-hexosaminidase were studied for 6 weeks after permanent bile duct occlusion (19 animals) or sham operation (5 animals). The bile duct-occluded animals had a stable bilirubinemia throughout the observation period. The median level of beta-glucuronidase in controls was 0.45 U/l. In jaundiced animals the median level was 1.09 at 0.5 weeks, 1.28 at 2 weeks, and 1.58 at 6 weeks after bile duct occlusion. The median level of beta-hexosaminidase in controls was 18.5 U/l. In jaundiced animals the median level was 18.0 at 0.5 weeks, 20.8 at 2 weeks, and 53.3 at 6 weeks after operation. Compared with beta-glucuronidase, prominent elevation of the beta-hexosaminidase level appeared much later after bile duct obstruction, which might suggest a closer association with reticuloendothelial system function for the latter enzyme.
在永久性胆管阻塞（19只动物）或假手术（5只动物）后，对溶酶体酶β-葡萄糖醛酸酶和β-己糖胺酶的血浆水平进行了为期6周的研究。胆管阻塞的动物在整个观察期内有稳定的胆红素血症。对照组中β-葡萄糖醛酸酶的中位数水平为0.45 U/l。在黄疸动物中，胆管阻塞后0.5周时中位数水平为1.09，2周时为1.28，6周时为1.58。对照组中β-己糖胺酶的中位数水平为18.5 U/l。在黄疸动物中，术后0.5周时中位数水平为18.0，2周时为20.8，6周时为53.3。与β-葡萄糖醛酸酶相比，胆管阻塞后β-己糖胺酶水平的显著升高出现得要晚得多，这可能表明后一种酶与网状内皮系统功能的关系更为密切。
