Tsushima K, Sakata Y
First Dept. of Internal Medicine, Hirosaki University, School of Medicine, Japan.
Gan To Kagaku Ryoho. 1998 Feb;25(3):321-6.
The recurrence rate of resected gastric cancer with curative intent was around 20%. When early gastric cancer was excluded, the rate was around 30%. Peritoneal dissemination accounted for half the recurrences, and was followed by hematogeneous metastasis, including hepatic metastasis. Chemotherapy was the main treatment modality because the possibility of curative resection was very low. Systemic chemotherapies based on biochemical modulation, particularly CDDP/5-FU therapy, have been routinely performed. For localized diseases, loco-regional therapies like drug administration via hepatic artery and intraperitoneal administration have been also applied.
具有治愈意图的切除性胃癌复发率约为20%。排除早期胃癌后,该比率约为30%。腹膜播散占复发的一半,其次是血行转移,包括肝转移。化疗是主要的治疗方式,因为根治性切除的可能性非常低。基于生化调节的全身化疗,特别是顺铂/5-氟尿嘧啶疗法,已常规进行。对于局限性疾病,也应用了诸如经肝动脉给药和腹腔内给药等局部区域疗法。