通过拟交感神经刺激诱导大鼠非典型前列腺增生
Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation.
作者信息
Golomb E, Kruglikova A, Dvir D, Parnes N, Abramovici A
机构信息
Department of Pathology, Sackler Medical Faculty, Tel-Aviv University, Israel.
出版信息
Prostate. 1998 Feb 15;34(3):214-21. doi: 10.1002/(sici)1097-0045(19980215)34:3<214::aid-pros9>3.0.co;2-h.
BACKGROUND
Prostatic innervation may participate in its homeostasis and growth. alpha-Adrenergic inhibition alleviates clinical symptoms in benign prostatic hyperplasia. However, the prostatic effect of adrenergic agonists has not been investigated. This study deals with the prostatic effect of subchronic sympathomimetic stimulation.
METHODS
Male rats received daily subcutaneous injections of the alpha-adrenergic agonist phenylephrine, 1, 10, or 20 mg/kg per day, the beta-adrenergic agonist isoproterenol, 1, 2.5 or 5 mg/kg per day, or saline, for 30 days, and the prostates were removed for histopathological examination.
RESULTS
Phenylephrine induced atypical prostatic hyperplasia, characterized by piling-up with papillary and cribriform patterns, and budding-out of epithelial cells. It decreased prostatic secretions and total weight. Similar results were observed in orchidectomized rats receiving exogenous testosterone supplementation. Isoproterenol had no prostatic morphological effect.
CONCLUSIONS
These results raise the possibility that sympathetic stimuli play a role in normal and aberrant growth and differentiation of prostatic epithelium, and suggests neurostimulants-treated animals as a model to study the etiology and development of prostatic hyperplasia.
背景
前列腺神经支配可能参与其体内平衡和生长。α-肾上腺素能抑制可缓解良性前列腺增生的临床症状。然而，肾上腺素能激动剂对前列腺的作用尚未得到研究。本研究探讨亚慢性拟交感神经刺激对前列腺的影响。
方法
雄性大鼠每天皮下注射α-肾上腺素能激动剂去氧肾上腺素，剂量为每天1、10或20mg/kg，β-肾上腺素能激动剂异丙肾上腺素，剂量为每天1、2.5或5mg/kg，或生理盐水，持续30天，然后取出前列腺进行组织病理学检查。
结果
去氧肾上腺素诱导非典型前列腺增生，其特征为呈乳头状和筛状模式堆积以及上皮细胞芽出。它减少了前列腺分泌物和总重量。在接受外源性睾酮补充的去势大鼠中也观察到了类似结果。异丙肾上腺素对前列腺形态没有影响。
结论
这些结果增加了交感神经刺激在前列腺上皮正常和异常生长及分化中起作用的可能性，并提示将神经刺激剂处理的动物作为研究前列腺增生病因和发展的模型。
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