Milligan G, Grassie M A
Molecular Pharmacology Group, University of Glasgow, U.K.
Essays Biochem. 1997;32:49-60.
G-protein alpha-subunits are modified by combinations of fatty acyl groups. G-protein gamma-subunits are isoprenylated. These modifications play central roles in membrane association of the G-proteins. Attachment of long-chain fatty acyl chains to G-protein alpha-subunits via a thioester linkage allows the possibility of dynamic regulation of membrane attachment and function.
G蛋白α亚基通过脂肪酰基组合进行修饰。G蛋白γ亚基被异戊二烯化。这些修饰在G蛋白的膜结合中起核心作用。通过硫酯键将长链脂肪酰链连接到G蛋白α亚基上，使得膜结合和功能的动态调节成为可能。
