Selva-O'Callaghan A, Ordi-Ros J, Monegal-Ferran F, Martinez N, Cortes-Hernandez F, Vilardell-Tarres M
Department of Internal Medicine, Hospital General Vall D'Hebron, Spain.
Thromb Haemost. 1998 Feb;79(2):282-5.
To evaluate the usefulness of IgA antiphospholipid antibodies as markers of thrombosis and/or antiphospholipid antibody syndrome.
A cross-sectional study design in a tertiary, university-based, autoimmune reference hospital. Seven-hundred ninety-five patients classified into five different groups--autoimmune diseases (255), deep vein thrombosis (153), transitory ischemic attacks (108), obstetric complications (196), infectious diseases (83) and controls (81)--were tested for IgA, IgG and IgM aPL, and lupus anticoagulant. Plasma and serum samples were drawn for detection of aPL using an internationally standardized ELISA method and LA was carried out using coagulometric assays.
True IgA aPL were found only in two patients with systemic lupus erythematosus; these patients were also positive to IgG aPL.
The incidence of true positivity to IgA anticardiolipin antibodies is extremely low. Their determination was not helpful in diagnosing the antiphospholipid syndrome or in explaining thrombotic events or aPL related manifestations--fetal loss--in the groups studied.
评估IgA抗磷脂抗体作为血栓形成和/或抗磷脂抗体综合征标志物的实用性。
在一家以大学为基础的三级自身免疫性参考医院进行横断面研究设计。对795名患者进行了分类，分为五个不同组——自身免疫性疾病（255例）、深静脉血栓形成（153例）、短暂性脑缺血发作（108例）、产科并发症（196例）、传染病（83例）和对照组（81例）——检测其IgA、IgG和IgM抗磷脂抗体以及狼疮抗凝物。采集血浆和血清样本，采用国际标准化酶联免疫吸附测定法检测抗磷脂抗体，采用凝固法检测狼疮抗凝物。
仅在两名系统性红斑狼疮患者中发现了真正的IgA抗磷脂抗体；这两名患者的IgG抗磷脂抗体也呈阳性。
IgA抗心磷脂抗体真正阳性的发生率极低。在本研究的各组中，检测IgA抗心磷脂抗体无助于诊断抗磷脂综合征，也无法解释血栓形成事件或与抗磷脂抗体相关的表现——胎儿丢失。
