Horstman Lawrence L, Jy Wenche, Bidot Carlos J, Ahn Yeon S, Kelley Roger E, Zivadinov Robert, Maghzi Amir H, Etemadifar Masoud, Mousavi Seyed Ali, Minagar Alireza
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
J Neuroinflammation. 2009 Jan 20;6:3. doi: 10.1186/1742-2094-6-3.
This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP.
After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed.
The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.
这是一篇关于抗磷脂抗体（aPL）的批判性综述。大多数先前的综述聚焦于抗磷脂综合征（APS），这是一种常伴有神经功能障碍的血栓形成性疾病。我们提请注意最近的证据，即aPL可能与非血栓形成性自身免疫性疾病同样相关，特别是多发性硬化症和免疫性血小板减少症（ITP）。
在简要介绍历史之后，回顾了最近aPL靶抗原的大量增加。这意味着可能还存在更多的靶抗原。接着回顾了aPL在血栓形成中的理论，得出的结论是所有理论都有其价值，但aPL可能具有比目前所认识到的更多样化的病理后果。接下来，通过方法学差异解释了相互矛盾的结果。然后讨论了狼疮抗凝物（LA）。LA是血栓形成的最佳预测指标，但为何如此尚未定论。最后，综述了aPL在非血栓形成性疾病中的情况。
目前关于aPL的范式认为它们在血栓形成中很重要，但它们可能具有更广泛的临床意义，可能在神经病学领域具有特殊意义。
